| Registro completo |
| Provedor de dados: |
Braz. J. Genet.
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| País: |
Brazil
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| Título: |
In vitro and in vivo studies demonstrate non-mutagenicity of the herbicide metolachlor
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| Autores: |
Grisolia,Cesar Koppe
Ferrari,Iris
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| Data: |
1997-09-01
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| Ano: |
1997
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| Resumo: |
The herbicide metolachlor was evaluated for genotoxic potential. Metolachlor did not induce micronuclei in mice, however at 40 mg/kg it significantly decreased the percentage of polychromatic erythrocytes, which is a cytotoxic effect. Metolachlor did not induce chromosomal aberrations in human lymphocytes in vitro, but 2.0 mug/ml culture medium resulted in cytotoxicity, decreasing the mitotic index significantly. The indirect exposure test was carried out by adding plasma from metolachlor-pretreated rats to the human lymphocyte cultures. There was no indication of clastogenicity by metolachlor metabolites. On the other hand, plasma of cyclophosphamide-pretreated rats had a significant clastogenic effect
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-84551997000300009
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| Editor: |
Sociedade Brasileira de Genética
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| Relação: |
10.1590/S0100-84551997000300009
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Genetics v.20 n.3 1997
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| Direitos: |
info:eu-repo/semantics/openAccess
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